We previously reported that the degradation of prohibitin by the SCF(Skp2B) ubiquitin ligase results in a defect in the activity of p53.We also reported that MMTV-Skp2B transgenic mice develop mammary gland tumors that are characterized by an increased proteolytic cleavage of the insulin-like growth factor binding protein 4 (IGFBP-4), an inhibitor
Turner Signal Wire The article devoted to study of the fragment (so-called third Syro-Turkic fragment) of a Syrian Christian book from Khara-Khoto (the capital of the Tangut kingdom) written in Turkic language in Syriac script, which comes from the Turks who adopted Christianity from the Syrians in the XIII-XIV centuries in the region of the lake I
Background: Diabetes mellitus (DM) is a clinical syndrome with symptoms of hyperglycemia, urinary glucose excretion and disorder of insulin mechanism.Approximately 90-95% of diabetic patients suffer from type 2 DM.Various studies show that compliance to treatment of chronic disease in general is low.Compliance to eating or food frequency amongst DM
Summary: Monoallelic inactivation of CCCTC-binding factor (CTCF) in human cancer drives altered methylated genomic states, altered CTCF occupancy at promoter and enhancer regions, and deregulated global gene expression.In patients with T cell acute lymphoblastic leukemia (T-ALL), we find that acquired monoallelic CTCF-inactivating events drive subt